Reflecting the full breadth of research on bacteria, fungi, parasites, prions and viruses, PLOS Pathogens publishes outstanding original research and commentary that significantly advance the understanding of pathogens and how they interact with their host organisms.ScopeBacteria, fungi, parasites, prions and viruses cause a plethora of diseases that have important medical, agricultural, and economic consequences. Moreover, the study of microbes continues to provide novel insights into such fundamental processes as the molecular basis of cellular and organismal function.PLOS Pathogens reflects the full breadth of research in these areas by publishing outstanding original articles that significantly advance the understanding of pathogens and how they interact with their host organisms. Topics include (but are not limited to) adaptive and innate immune defenses as well as pathogen countermeasures, emerging pathogens, evolution, genomics and gene regulation, model host organisms, pathogen-cell biology, pathogenesis, prions, proteomics and signal transduction, rational vaccine design, structural biology, and virulence factors.The journal will not consider purely descriptive studies, such as those that solely identify a new genomic sequence of a related pathogen or a series of related pathogens, the isolation of pathogen variants, or a new strain or type based only on sequence analysis or correlative studies of host and pathogen genotypes.Genomics studies, which include functional predictions or inferences based on genome sequence analysis, will also require additional experimental validation that directly tests the prediction/inference and yields novel conclusions about mechanistic models or pathogenesis. Instances where inferences about potential functions can be supported by association studies of genotype-phenotype combined with existing functional data, may also be appropriate, pending approval by the editors. If a paper provides novel mechanistic insight but lacks functional validation, it may be considered on a case-by-case basis. We encourage authors to submit a presubmission inquiry to determine whether a given study might fit these guidelines. Genomics submissions may go through an initial consultation by our Genomics Editors.
反映了对细菌、真菌、寄生虫、朊病毒和病毒的全面研究，PLoS病原体发表了杰出的原始研究和评论，显著提高了对病原体及其与宿主生物体相互作用的理解。范围细菌、真菌、寄生虫、朊病毒和病毒会导致过多的疾病，这些疾病对医疗、农业和经济都有重要影响。此外，微生物的研究继续为细胞和组织功能的分子基础等基本过程提供新的见解。《公共科学图书馆病原体》通过发表优秀的原创文章，反映了这些领域的全面研究，这些文章极大地促进了对病原体及其与宿主有机体相互作用的理解。主题包括（但不限于）适应性和先天免疫防御以及病原体对策、新出现的病原体、进化、基因组学和基因调控、模型宿主生物体、病原体细胞生物学、发病机制、朊病毒、蛋白质组学和信号转导、合理的疫苗设计、结构生物学和毒力因子。该杂志不会考虑纯粹的描述性研究，例如那些仅识别相关病原体或一系列相关病原体的新基因组序列、分离病原体变体或仅基于序列分析或宿主和病原体基因型相关研究的新菌株或类型的研究。基因组学研究，包括基于基因组序列分析的功能预测或推断，还需要额外的实验验证，直接测试预测/推断，并得出有关机械模型或发病机制的新结论。在编辑批准之前，基因型表型与现有功能数据的关联研究也可以支持潜在功能的推论。如果一篇论文提供了新的机械论见解，但缺乏功能验证，则可以根据具体情况加以考虑。我们鼓励作者提交一份审前调查，以确定给定的研究是否符合这些准则。基因组学提交可能需要我们的基因组学编辑进行初步咨询。
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