BIOCONJUGATE CHEMISTRY

Bioconjugate Chemistry provides centralized access to multidisciplinary, groundbreaking research in conjugation chemistry. It reports on key advances concerning the covalent attachment of active molecules to biopolymers, surfaces, and other materials. Coverage spans conjugation of antibodies and their fragments, nucleic acids and their analogs, liposomal components, and other biologically active molecules with each other or with any molecular groups that add useful properties. Topics include studies of conjugate preparation and characterization; in vivo applications of conjugate methodology; molecular biological aspects of antibodies, genetically engineered fragments, and other immunochemicals; and the relationships between conjugation chemistry and the biological properties of conjugates.

生物接合化学提供了对接合化学多学科、突破性研究的集中访问。报告了活性分子与生物聚合物、表面和其他材料共价结合的关键进展。覆盖范围包括抗体及其片段、核酸及其类似物、脂质体成分和其他生物活性分子相互结合或与任何增加有用性质的分子群结合。主题包括共轭制备和表征的研究；共轭方法的体内应用；抗体、基因工程片段和其他免疫化学物质的分子生物学方面；共轭化学与共轭物生物学性质之间的关系。