BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. Given the complex regulation of gene expression by a vast network of miRNA's, manuscripts describing the regulation of (disease-associated) genes by single miRNAs will only be considered if they provide genuine, novel insight in a disease mechanism. Further, studies restricted to a single cell line will not be considered unless they present truly novel insights.

BBA分子基础疾病涉及疾病过程和人类疾病模型的生物化学和分子遗传学。该期刊涵盖衰老，癌症，代谢，神经和免疫疾病等方面。特别鼓励使用动物模型来阐明每种条件下的生化和机械洞察力的手稿。手稿应强调疾病途径的潜在机制，并为理解和/或治疗这些疾病提供新的贡献。如果没有全面审核，可能会拒绝高度描述性和方法开发提交。鉴于巨大的miRNA网络对基因表达的复杂调控，只有在描述单一miRNA对（疾病相关）基因的调控时才会考虑如果它们提供真正的，新颖的疾病机制洞察力的手稿。此外，除非他们提出真正新颖的见解，否则不会考虑限于单细胞系的研究。