Journal of Neuroinflammation

Published by BioMed Central. ISSN: 1742-2094.Journal of Neuroinflammation is an Open Access, peer-reviewed online journal that focuses on innate immunological responses of the central nervous system, involving microglia, astrocytes, cytokines, chemokines, and related molecular processes. 'Neuroinflammation' is an encapsulization of the idea that microglial and astrocytic responses and actions in the central nervous system have a fundamentally inflammation-like character, and that these responses are central to the pathogenesis and progression of a wide variety of neurological disorders. This idea has revolutionized our understanding of Alzheimer's disease, where it originated, and now has applications to other neurodegenerative diseases, to ischemic/toxic diseases, and even to normal brain development. Neuroinflammation incorporates a wide spectrum of complex cellular responses that include microglia and astrocytes, cytokines and chemokines, complement proteins, acute phase proteins, oxidative injury, and related molecular processes. Neuroinflammation is a new and rapidly expanding field that has revolutionized our understanding of chronic neurological diseases. This field has grown to encompass researchers with backgrounds in many diverse fields, including pathology, biochemistry, molecular biology, genetics, clinical medicine, and epidemiology. Important contributions to this field have come from work with populations, with patients, with postmortem tissues, with animal models, and with in vitro systems. The Journal of Neuroinflammation will bring together work focusing on common pathogenic processes, and provide a forum for integrative reviews and commentaries on this field.

由生物医学中心出版。ISSN:1742-2094。《神经炎症杂志》是一份开放获取、同行评议的在线杂志，关注中枢神经系统的先天免疫反应，包括小胶质细胞、星形胶质细胞、细胞因子、趋化因子和相关的分子过程。“神经炎症”是对中枢神经系统的小胶质细胞和星形细胞反应和行为具有基本炎症样特征的一种概括，这些反应是多种神经系统疾病的发病机制和进展的核心。这个想法彻底改变了我们对阿尔茨海默氏症的理解，它起源于阿尔茨海默氏症，现在已经应用于其他神经退行性疾病，缺血性/毒性疾病，甚至是正常的大脑发育。神经炎症包括一系列复杂的细胞反应，包括小胶质细胞和星形胶质细胞、细胞因子和趋化因子、补体蛋白、急性期蛋白、氧化损伤和相关的分子过程。神经炎症是一个迅速发展的新领域，它彻底改变了我们对慢性神经疾病的认识。这一领域的研究人员已成长为涵盖许多不同领域的背景，包括病理学、生物化学、分子生物学、遗传学、临床医学和流行病学。这一领域的重要贡献来自于对人群、患者、死后组织、动物模型和体外系统的研究。神经炎症杂志将集中研究常见的致病过程，并为该领域的综合评论提供一个论坛。