DRUG METABOLISM AND DISPOSITION

Drug Metabolism and Disposition will consider for publication manuscripts describing the results of original research that contribute significant and novel information on xenobiotic metabolism, transport, and disposition. The term xenobiotic includes therapeutic agents as well as environmental chemicals. Research may involve the use of in vivo or in vitro approaches, including cultured cells and heterologous expression systems. Manuscripts that describe mechanistic aspects of xenobiotic metabolism and transport as well as those examining mechanisms that affect expression and regulation of drug-metabolizing enzymes and transporters, including genetic variability, are encouraged. Manuscripts concerned with genetic, nutritional, or hormonal factors that influence the biological fate of chemicals are also of interest, as are those that address the toxicologic consequences of xenobiotic metabolism. We continue to welcome manuscripts describing metabolite identification and/or identification of specific enzymes responsible for particular metabolic pathways, provided that the studies are thorough and rigorous. Manuscripts presenting the results of pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response and/or address clearly defined hypotheses are invited. Studies lacking mechanistic insight or dealing only with descriptive parent drug pharmacokinetics are not encouraged.

药物代谢与处置将考虑发表原创性研究结果的原稿，这些原稿对异种生物代谢、转运和处置方面提供重要和新颖的信息。外源生物一词包括治疗剂和环境化学品。研究可能涉及使用体内或体外方法，包括培养细胞和异种表达系统。鼓励编写描述异种代谢和转运机制方面的手稿，以及研究影响药物代谢酶和转运体表达和调控的机制的手稿，包括遗传变异的手稿。与影响化学物质生物命运的遗传、营养或激素因素有关的手稿也很有价值，处理异种生物代谢的毒理后果的手稿也很有价值。我们继续欢迎描述代谢物鉴定和/或负责特定代谢途径的特定酶的鉴定的手稿，只要研究是彻底和严格的。现邀请提交药物动力学/药效学研究结果的手稿，说明药物处置和反应机制以及/或明确界定的假设。不鼓励缺乏机械洞察力的研究或只处理描述性的母体药物药代动力学。