DISEASE MARKERS

The journal publishes original research findings (and reviews solicited by the Editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may be a genetic host factor predisposing to the disease or the occurrence of cell-surface markers, enzymes or other components, either in altered forms, abnormal concentrations or with abnormal tissue distribution. This journal is designed to provide a forum for publications dealing with original observations in this developing field on any aspect of the general topic including: Identification of new genetic or non-genetic markers (e.g., cell-surface antigens, serum proteins, intra- and extra-cellular enzymes, cytogenic markers and DNA-sequences); Population studies of new and existing markers, designed to elucidate information on their normal distribution as well as that in disease states; Amplification of knowledge about existing markers; Family studies of markers in disease; New techniques for identification and/or isolation of important marker molecules; Use of monoclonal antibodies for the definition of molecular structures associated with disease markers; Identification of disease-associated abnormalities in DNA using recombinant DNA techniques, gene-cloning and DNA restriction enzyme fragment polymorphisms; Identification of markers identifying malignantly transformed neoplastic cells

该杂志发表了关于识别与疾病过程相关的标记物的原始研究结果(以及编辑征求的评论)，无论这些标记物是否是病变的组成部分。疾病标记物可能是诱发疾病的遗传宿主因子，也可能是细胞表面标记物、酶或其他成分的发生，以改变的形式、异常的浓度或异常的组织分布。本杂志旨在为出版物提供一个论坛，讨论这一发展中领域中关于一般主题的任何方面的原始观察，包括:识别新的遗传或非遗传标记(如细胞表面抗原、血清蛋白、细胞内外酶、细胞遗传学标记和dna序列);新标记物和现有标记物的人口研究，旨在阐明其正态分布和疾病状态的信息;扩大现有标记的知识;疾病标志物的家庭研究;识别和/或分离重要标记分子的新技术;利用单克隆抗体定义与疾病标志物相关的分子结构;利用重组DNA技术、基因克隆和DNA限制性内切酶片段多态性鉴定疾病相关的DNA异常;识别恶性转化肿瘤细胞的标记物。