CHIRALITY

The main aim of the journal is to publish scientific work on the role of molecular asymmetry in both biologically active and non-biologically active molecules in respect to their pharmacological biological and chemical properties. Drugs pesticides and other xenobiotics will be a major interest. Papers on the chemistry (physiochemical preparative synthetic and analytical) pharmacology clinical pharmacology toxicology and other biological aspects of chiral molecules will be published. Among the topics to be covered are stereospecific synthesis stereoselective analysis preparative separation of chiral molecules the influence of chirality on pharmacokinetics (absorption distribution protein binding biotransformation etc.) the influence of chirality on pharmacodynamics (drug-receptor interactions pharmacological and toxicological activity) and the influence of chirality on clinical pharmacology (therapeutic index and response bioavailability adverse drug reactions drug-drug interactions). Papers will also be published on regulatory and legal aspects in the development testing and marketing of chiral compounds. In addition to original research papers the journal will publish brief reviews short communications and conference reports. Book reviews will also appear.

该杂志的主要目的是发表关于分子不对称在生物活性和非生物活性分子的药理、生物和化学性质方面的作用的科学工作。药物、杀虫剂和其他外源性药物将是主要的研究对象。将发表手性分子的化学(生化学制备、合成和分析)、药理学、临床药理学、毒理学等生物学方面的论文。要覆盖的主题包括立体定向合成立体选择分析制备的手性分子分离手性对药物动力学的影响(吸收分布蛋白结合生物转化等)手性的影响在药效学(drug-receptor交互药理学和毒理学活动)和手性对临床药理学(治疗指数的影响和应对生物利用度药品不良反应药物之间交互)。还将发表关于手性化合物开发、检测和销售的管制和法律方面的论文。除了原始的研究论文，该杂志还将发表简短的评论、简短的交流和会议报告。书评也会出现。