BIOORGANIC & MEDICINAL CHEMISTRY

Bioorganic & Medicinal Chemistry publishes complete accounts of research of outstanding significance and timeliness on all aspects of molecular interactions at the interface of chemistry and biology, together with critical review articles. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents.The Journal welcomes papers on:the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targetsthe reporting of the discovery, design or optimization of potent new compounds or biological agentsthe analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental datathe reporting of "first-in-class" new therapeutic compoundsthe chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanismmethodological advances that are chemistry-based and which significantly impact on medicine or biologythe preparation and examination of biotherapeutics for the treatment of pathophysiological disease statesthe development of materials for specific therapeutic targetingAll manuscripts will be rigorously peer-reviewed by independent experts following an initial assessment by the Editors. Please note that BMC is not suitable for straightforward reports of incremental advances. Above all the presentation of a rational basis and a sound underlying hypothesis for the work is of particular importance, whatever its exact field.

《生物有机与药物化学》发表了关于化学与生物学界面上分子相互作用各方面的显著意义和及时性的完整研究报告，并发表了评论文章。该杂志发表了关于药物化学、化学生物学和药物发现与设计的实验结果的报告，强调了这些领域新的和新出现的进展和概念。这本杂志的目的是促进人们更好地了解生命过程的分子水平、活生物体以及它们与化学试剂的相互作用。期刊欢迎发表以下论文：已建立或新的疾病靶点的药物化学和相关生物学（包括靶点识别和确认）；发现、设计或优化有效新化合物或生物制剂的报告；利用体外和体内模型分析和讨论与药物设计和作用相关的结构-活性关系和药理学问题，包括在与实验数据密切相关时使用计算技术；“一流”新型治疗化合物的报道；显著提高生物机制知识的化学生物学或生物有机/生物无机化学；以化学为基础，对医学或生物学有重大影响的方法学进展；病理生理疾病状态生物治疗的制备与检测；特定治疗靶向材料的开发。所有手稿将由独立专家在编辑初步评估后进行严格的同行评审。请注意，BMC不适合直接报告增量预付款。最重要的是，无论工作的确切领域是什么，合理的基础和合理的基本假设的提出都是特别重要的。