聚丙烯纳米塑料与有机磷阻燃剂联合暴露对斑马鱼发育和神经毒性的影响

来源：中国环境科学杂志2024年第11期北京时间：

作者：周鑫, 万可维, 倪安煜, 方露, 包君婷, 陈嘉怡, 王慧利, 钱秋慧, 王泽君, 闫瑾

单位：苏州科技大学环境科学与工程学院, 江苏 苏州 215009

摘要：Using zebrafish as a model organism, this study investigated the toxic effects and the relevant mechanisms for the exposure to 2-ethylhexyl diphenyl phosphate (EHDPP), as well as the co-exposure to it with polypropylene nanoplastics (PP-NPs). The results indicated that the acute toxicity LC50value of EHDPP for zebrafish at 120hours post-fertilization (hpf) was 2240μg/L. Acute exposure to 250 and 500μg/L EHDPP resulted in developmental delays and deformities in zebrafish, inhibited their swimming activity and reduced the sensitivity to environmental stimuli. At the molecular level, EHDPP concentrations of 50, 125, and 250μg/L significantly decreased the activities of superoxide dismutase (SOD) and catalase (CAT) compared to the control group, leading to excessive accumulation of reactive oxygen species (ROS) and increased malondialdehyde (MDA) levels, which in turn induced inflammation and accelerated cell apoptosis. Although PP-NPs showed limited toxicity to zebrafish, the co-exposure to 100μg/L PP-NPs and EHDPP reduced the LC50 value to 494.6μg/L, significantly enhancing the toxicity of EHDPP and lowering the threshold for its adverse effects, resulting in noticeable developmental and neurotoxic effects at lower concentrations. This study highlights the synergistic toxic effects that can arise from the coexistence of nanoplastics and organic pollutants, providing important insights into the risks associated with microplastics and organic contaminants in real environmental scenarios.

关键词：EHDPP,斑马鱼,神经毒性,氧化应激,炎性响应

基金资助：国家自然科学基金资助项目(22106118)