质谱成像技术在环境领域的应用

来源：中国环境科学杂志2024年第11期北京时间：

作者：张玉林, 周杨浩, 陈忠礼, 陈瑞煌, 邵迎

单位：1. 重庆大学环境与生态学院, 重庆 400044;2. 三峡库区生态环境教育部重点实验室, 重庆 400044

摘要：Through literature collection, study and bibliometric analysis of Citespace literature, this paper summarizes the development history of mass spectrometry imaging (MSI) technology and its latest application status in the environmental field. Combined with the current research bottleneck in the environmental field, the development prospect of MSI is deeply discussed. MSI, as a new technology integrating high sensitivity mass spectrometry and high precision spatial resolution imaging, can directly collect and identify molecular information from the sample. In the field of environmental toxicology and monitoring, MSI, on one hand, can demonstrate the distribution, location and quantify the pollutants and their transformed products in environmental media or within biological tissues, cells and even sub-cells, and thus reveal the target of pollutant action. On the other hand, it can analyse the characteristics and mechanisms of pollutants' bioaccumulation, biotransformation and metabolic activation. In summary, the application of MSI in the environmental field has important scientific significance, providing a new perspective in the monitoring of water, air and soil pollution, particularly for in situ identification of pollutants and analysis of their toxic effects. Besides, it provides a scientific basis for the risk screening, assessment and control of pollutants.

关键词：质谱成像,环境毒理,环境监测,污染物分布,毒性机制解析

基金资助：国家自然科学基金青年基金资助项目(51909015)